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Research Article

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

  • Mirco Schmolke,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Balaji Manicassamy,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Lindomar Pena,

    Affiliation: Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Troy Sutton,

    Affiliation: Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Rong Hai,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Zsuzsanna T. Varga,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Benjamin G. Hale,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • John Steel,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Microbiology and Immunology, School of Medicine, Emory University, Rollins Research Center, Atlanta, Georgia, United States of America

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  • Daniel R. Pérez,

    Affiliation: Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Adolfo García-Sastre mail

    adolfo.garcia-sastre@mssm.edu

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: August 11, 2011
  • DOI: 10.1371/journal.ppat.1002186

About the Authors

Mirco Schmolke, Balaji Manicassamy, Rong Hai, Zsuzsanna T. Varga, Benjamin G. Hale, John Steel, Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
Lindomar Pena, Troy Sutton, Daniel R. Pérez
Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
John Steel
Department of Microbiology and Immunology, School of Medicine, Emory University, Rollins Research Center, Atlanta, Georgia, United States of America
Adolfo García-Sastre
Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine, New York, New York, United States of America
Adolfo García-Sastre
Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: adolfo.garcia-sastre@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS BM LP DRP AGS. Performed the experiments: MS BM LP TS RH BGH ZTV JS. Analyzed the data: MS LP DRP AGS. Contributed reagents/materials/analysis tools: MS LP ZTV JS. Wrote the paper: MS BM LP RH ZTV BGH JS DRP AGS.