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Research Article

A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes

  • Meenu Kesarwani,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

    Current address: Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio, United States of America

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  • Ronen Hazan,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Jianxin He,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • YokAi Que,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Yiorgos Apidianakis,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Biliana Lesic,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

    Current address: Danone Research, RD128, Palaiseau, France

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  • Gaoping Xiao,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Valérie Dekimpe,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Sylvain Milot,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Eric Deziel,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • François Lépine,

    Affiliation: INRS-Institut Armand-Frappier, Laval, Québec, Canada

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  • Laurence G. Rahme mail

    rahme@molbio.mgh.harvard.edu

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.ppat.1002192

About the Authors

Meenu Kesarwani, Ronen Hazan, Jianxin He, YokAi Que, Yiorgos Apidianakis, Biliana Lesic, Gaoping Xiao, Laurence G. Rahme
Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
Meenu Kesarwani, Ronen Hazan, Jianxin He, YokAi Que, Yiorgos Apidianakis, Biliana Lesic, Gaoping Xiao, Laurence G. Rahme
Shriners Burns Institute and Massachusetts General Hospital, Boston, Massachusetts, United States of America
Valérie Dekimpe, Sylvain Milot, Eric Deziel, François Lépine
INRS-Institut Armand-Frappier, Laval, Québec, Canada

Corresponding Author

Email: rahme@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK LGR. Performed the experiments: MK RH JH YA YQ BL GX VD SM. Analyzed the data: MK ED FL LGR. Contributed reagents/materials/analysis tools: FL LGR. Wrote the paper: MK LGR.