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Research Article

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

  • Jonathan J. Wilksch mail,

    wilkschj@unimelb.edu.au

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Ji Yang,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Abigail Clements,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

    Current address: Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London, United Kingdom.

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  • Jacinta L. Gabbe,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Kirsty R. Short,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Hanwei Cao,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Rosalia Cavaliere,

    Affiliation: The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia

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  • Catherine E. James,

    Affiliation: The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia

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  • Cynthia B. Whitchurch,

    Affiliation: The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia

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  • Mark A. Schembri,

    Affiliation: Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

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  • Mary L. C. Chuah,

    Affiliation: Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

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  • Zhao-Xun Liang,

    Affiliation: Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

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  • Odilia L. Wijburg,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Adam W. Jenney,

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

    Current address: Infectious Diseases Unit and Microbiology Department, Alfred Hospital, Prahran, Victoria, Australia.

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  • Trevor Lithgow,

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • Richard A. Strugnell

    Affiliation: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

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  • Published: August 25, 2011
  • DOI: 10.1371/journal.ppat.1002204

About the Authors

Jonathan J. Wilksch, Ji Yang, Abigail Clements, Jacinta L. Gabbe, Kirsty R. Short, Hanwei Cao, Odilia L. Wijburg, Adam W. Jenney, Richard A. Strugnell
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
Rosalia Cavaliere, Catherine E. James, Cynthia B. Whitchurch
The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia
Mark A. Schembri
Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
Mary L. C. Chuah, Zhao-Xun Liang
Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
Trevor Lithgow
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Corresponding Author

Email: wilkschj@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JJW JY AC JLG CBW OLW RAS. Performed the experiments: JJW JY KRS HC RC CEJ MLCC ZXL. Analyzed the data: JJW JY AC JLG KRS CBW MLCC ZXL OLW TL RAS. Contributed reagents/materials/analysis tools: MLCC ZXL MAS AWJ. Wrote the paper: JJW JY TL RAS.