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Research Article

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

  • Alejandra Borjabad,

    Affiliation: Molecular Virology Division, St. Luke's-Roosevelt Hospital Center and Columbia University, New York, New York, United States of America

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  • Susan Morgello,

    Affiliation: Department of Pathology and Neuroscience, The Mount Sinai Medical Center, New York, New York, United States of America

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  • Wei Chao,

    Affiliation: Molecular Virology Division, St. Luke's-Roosevelt Hospital Center and Columbia University, New York, New York, United States of America

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  • Seon-Young Kim,

    Affiliation: Human Genomics Laboratory, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea

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  • Andrew I. Brooks,

    Affiliation: Department of Genetics, Environmental and Occupational Health Science Institute (EOHSI), Rutgers University, Piscataway, New Jersey, United States of America

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  • Jacinta Murray,

    Affiliation: Department of Pathology and Neuroscience, The Mount Sinai Medical Center, New York, New York, United States of America

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  • Mary Jane Potash,

    Affiliation: Molecular Virology Division, St. Luke's-Roosevelt Hospital Center and Columbia University, New York, New York, United States of America

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  • David J. Volsky mail

    djv4@columbia.edu

    Affiliation: Molecular Virology Division, St. Luke's-Roosevelt Hospital Center and Columbia University, New York, New York, United States of America

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  • Published: September 01, 2011
  • DOI: 10.1371/journal.ppat.1002213

About the Authors

Alejandra Borjabad, Wei Chao, Mary Jane Potash, David J. Volsky
Molecular Virology Division, St. Luke's-Roosevelt Hospital Center and Columbia University, New York, New York, United States of America
Susan Morgello, Jacinta Murray
Department of Pathology and Neuroscience, The Mount Sinai Medical Center, New York, New York, United States of America
Seon-Young Kim
Human Genomics Laboratory, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea
Andrew I. Brooks
Department of Genetics, Environmental and Occupational Health Science Institute (EOHSI), Rutgers University, Piscataway, New Jersey, United States of America

Corresponding Author

Email: djv4@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJV SM AB SYK. Performed the experiments: AB WC JM SYK AIB. Analyzed the data: DJV AB SYK MJP SM. Contributed reagents/materials/analysis tools: SM AIB. Wrote the paper: DJV AB MJP SM.