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Research Article

Discovery of the First Insect Nidovirus, a Missing Evolutionary Link in the Emergence of the Largest RNA Virus Genomes

  • Phan Thi Nga equal contributor,

    equal contributor Contributed equally to this work with: Phan Thi Nga, Maria del Carmen Parquet, Chris Lauber

    Affiliation: Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

    PTN, MdCP, and CL are joint first authors on this work.

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  • Maria del Carmen Parquet equal contributor,

    equal contributor Contributed equally to this work with: Phan Thi Nga, Maria del Carmen Parquet, Chris Lauber

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

    PTN, MdCP, and CL are joint first authors on this work.

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  • Chris Lauber equal contributor,

    equal contributor Contributed equally to this work with: Phan Thi Nga, Maria del Carmen Parquet, Chris Lauber

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

    PTN, MdCP, and CL are joint first authors on this work.

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  • Manmohan Parida,

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Takeshi Nabeshima,

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Fuxun Yu,

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Nguyen Thanh Thuy,

    Affiliation: Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Shingo Inoue,

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Takashi Ito,

    Affiliation: Department of Biochemistry, Graduate School of Medical Science, Nagasaki University, Nagasaki, Japan

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  • Kenta Okamoto,

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Akitoyo Ichinose,

    Affiliation: Central Laboratory, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

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  • Eric J. Snijder,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Kouichi Morita mail,

    moritak@nagasaki-u.ac.jp (KM); a.e.gorbalenya@lumc.nl (AEG)

    Affiliation: Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan

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  • Alexander E. Gorbalenya mail

    moritak@nagasaki-u.ac.jp (KM); a.e.gorbalenya@lumc.nl (AEG)

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: September 08, 2011
  • DOI: 10.1371/journal.ppat.1002215

About the Authors

Phan Thi Nga, Nguyen Thanh Thuy
Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Maria del Carmen Parquet, Manmohan Parida, Takeshi Nabeshima, Fuxun Yu, Shingo Inoue, Kenta Okamoto, Kouichi Morita
Department of Virology, Institute of Tropical Medicine, Global COE Program, Nagasaki University, Nagasaki, Japan
Chris Lauber, Eric J. Snijder, Alexander E. Gorbalenya
Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
Takashi Ito
Department of Biochemistry, Graduate School of Medical Science, Nagasaki University, Nagasaki, Japan
Akitoyo Ichinose
Central Laboratory, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KM. Performed the experiments: PTN MdCP MP TN FY NTT SI TI KO AI . Analyzed the data: MdCP EJS KM AEG. Contributed reagents/materials/analysis tools: AEG. Wrote the paper: CL MdCP KM EJS AEG. Conceived and designed computational research: AEG CL. Conducted computational research: CL. Analyzed the computational data: CL AEG.