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Research Article

Murine Gamma-herpesvirus Immortalization of Fetal Liver-Derived B Cells Requires both the Viral Cyclin D Homolog and Latency-Associated Nuclear Antigen

  • Xiaozhen Liang,

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Clinton R. Paden,

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Immunology and Molecular Pathogenesis Graduate Program, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Francine M. Morales,

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Microbiology and Molecular Genetics Graduate Program, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Ryan P. Powers,

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Immunology and Molecular Pathogenesis Graduate Program, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Joshy Jacob,

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Samuel H. Speck mail

    sspeck@emory.edu

    Affiliations: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Published: September 08, 2011
  • DOI: 10.1371/journal.ppat.1002220

About the Authors

Xiaozhen Liang, Clinton R. Paden, Francine M. Morales, Ryan P. Powers, Joshy Jacob, Samuel H. Speck
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
Xiaozhen Liang, Joshy Jacob, Samuel H. Speck
Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
Clinton R. Paden, Ryan P. Powers
Immunology and Molecular Pathogenesis Graduate Program, Emory University School of Medicine, Atlanta, Georgia, United States of America
Francine M. Morales
Microbiology and Molecular Genetics Graduate Program, Emory University School of Medicine, Atlanta, Georgia, United States of America

Corresponding Author

Email: sspeck@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XL CRP JJ RPP SHS. Performed the experiments: XL CRP FMM RPP. Analyzed the data: XL CRP RPP JJ SHS. Contributed reagents/materials/analysis tools: FMM CRP RPP JJ. Wrote the paper: XL CRP JJ SHS.