Advertisement
Research Article

APOBEC3A Is a Specific Inhibitor of the Early Phases of HIV-1 Infection in Myeloid Cells

  • Gregory Berger,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Stéphanie Durand,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Guillaume Fargier,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Xuan-Nhi Nguyen,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Stéphanie Cordeil,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Serge Bouaziz,

    Affiliation: UMR 8015 CNRS, University Paris Descartes, Paris, France

    X
  • Delphine Muriaux,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Jean-Luc Darlix,

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Andrea Cimarelli mail

    acimarel@ens-lyon.fr

    Affiliations: Department of Human Virology, ENS-L, Lyon, France, INSERM, U758, Lyon, France, University of Lyon, Lyon I, IFR128, Lyon, France

    X
  • Published: September 22, 2011
  • DOI: 10.1371/journal.ppat.1002221

About the Authors

Gregory Berger, Stéphanie Durand, Guillaume Fargier, Xuan-Nhi Nguyen, Stéphanie Cordeil, Delphine Muriaux, Jean-Luc Darlix, Andrea Cimarelli
Department of Human Virology, ENS-L, Lyon, France
Gregory Berger, Stéphanie Durand, Guillaume Fargier, Xuan-Nhi Nguyen, Stéphanie Cordeil, Delphine Muriaux, Jean-Luc Darlix, Andrea Cimarelli
INSERM, U758, Lyon, France
Gregory Berger, Stéphanie Durand, Guillaume Fargier, Xuan-Nhi Nguyen, Stéphanie Cordeil, Delphine Muriaux, Jean-Luc Darlix, Andrea Cimarelli
University of Lyon, Lyon I, IFR128, Lyon, France
Serge Bouaziz
UMR 8015 CNRS, University Paris Descartes, Paris, France

Corresponding Author

Email: acimarel@ens-lyon.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GB SD AC JLD. Performed the experiments: GB SD GF XNN SC SB DM. Analyzed the data: GB SD SB DM JLD AC. Wrote the paper: GB JLD AC. Performed qRT-PCR analyses: SD. Performed DuoLink experiments: GF. Set up the qPCR method used here: XNN. Performed experiments in THP-1 cells: SC. Chemically synthesized Vpx: SB. Collected and analyzed immunofluorescence and DuoLink data: DM. All authors discussed and commented on the results and the manuscript.