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Research Article

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

  • Ryan S. Noyce,

    Affiliations: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada

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  • Daniel G. Bondre,

    Affiliations: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada

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  • Michael N. Ha,

    Affiliations: IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Canada

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  • Liang-Tzung Lin,

    Affiliations: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada

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  • Gary Sisson,

    Affiliations: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada

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  • Ming-Sound Tsao,

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Canada, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada

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  • Christopher D. Richardson mail

    chris.richardson@dal.ca.

    Affiliations: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada

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  • Published: August 25, 2011
  • DOI: 10.1371/journal.ppat.1002240

About the Authors

Ryan S. Noyce, Daniel G. Bondre, Liang-Tzung Lin, Gary Sisson, Christopher D. Richardson
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
Ryan S. Noyce, Daniel G. Bondre, Michael N. Ha, Liang-Tzung Lin, Gary Sisson, Christopher D. Richardson
IWK Health Sciences Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada
Michael N. Ha, Ming-Sound Tsao
Department of Medical Biophysics, University of Toronto, Toronto, Canada
Ming-Sound Tsao
Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada
Christopher D. Richardson
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada

Corresponding Author

Email: chris.richardson@dal.ca.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RSN DGB CDR. Performed the experiments: RSN DGB GS CDR. Analyzed the data: RSN DGB LTL CDR. Contributed reagents/materials/analysis tools: MNH LTL MST. Wrote the paper: RSN CDR.