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Research Article

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

  • Leonie Unterholzner equal contributor,

    equal contributor Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

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  • Rebecca P. Sumner equal contributor,

    equal contributor Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

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  • Marcin Baran ,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

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  • Hongwei Ren ,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

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  • Daniel S. Mansur,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

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  • Nollaig M. Bourke,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

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  • Felix Randow,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Geoffrey L. Smith ,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

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  • Andrew G. Bowie mail

    agbowie@tcd.ie

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

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  • Published: September 08, 2011
  • DOI: 10.1371/journal.ppat.1002247

About the Authors

Leonie Unterholzner, Marcin Baran, Nollaig M. Bourke, Andrew G. Bowie
School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Rebecca P. Sumner, Hongwei Ren, Daniel S. Mansur, Geoffrey L. Smith
Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom
Felix Randow
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

Corresponding Author

Email: agbowie@tcd.ie

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LU RPS MB HR DSM GLS AGB. Performed the experiments: LU MB NMB RPS HR DSM. Analyzed the data: LU MB AGB RPS HR DSM GLS. Contributed reagents/materials/analysis tools: FR. Wrote the paper: LU RPS GLS AGB. Conceived the study: LU GLS AGB.