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Research Article

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

  • Christopher J. Vavricka equal contributor,

    equal contributor Contributed equally to this work with: Christopher J. Vavricka, Qing Li, Yan Wu

    Affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Qing Li equal contributor,

    equal contributor Contributed equally to this work with: Christopher J. Vavricka, Qing Li, Yan Wu

    Affiliations: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, School of Life Sciences, University of Science and Technology of China, Hefei, China

    X
  • Yan Wu equal contributor,

    equal contributor Contributed equally to this work with: Christopher J. Vavricka, Qing Li, Yan Wu

    Affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Jianxun Qi,

    Affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Mingyang Wang,

    Affiliations: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Graduate University, Chinese Academy of Sciences, Beijing, China

    X
  • Yue Liu,

    Affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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  • Feng Gao,

    Affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    X
  • Jun Liu,

    Affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Enguang Feng,

    Affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    X
  • Jianhua He,

    Affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China

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  • Jinfang Wang,

    Affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hong Liu,

    Affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hualiang Jiang,

    Affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • George F. Gao mail

    gaof@im.ac.cn

    Affiliations: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, School of Life Sciences, University of Science and Technology of China, Hefei, China, Graduate University, Chinese Academy of Sciences, Beijing, China, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China

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  • Published: October 20, 2011
  • DOI: 10.1371/journal.ppat.1002249

About the Authors

Christopher J. Vavricka, Qing Li, Yan Wu, Jianxun Qi, Mingyang Wang, Yue Liu, Jun Liu, George F. Gao
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Qing Li, George F. Gao
School of Life Sciences, University of Science and Technology of China, Hefei, China
Mingyang Wang, George F. Gao
Graduate University, Chinese Academy of Sciences, Beijing, China
Feng Gao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Enguang Feng, Jinfang Wang, Hong Liu, Hualiang Jiang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Jianhua He
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
George F. Gao
Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China

Corresponding Author

Email: gaof@im.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJV QL JQ GFG. Performed the experiments: CJV QL YW JQ MW YL. Analyzed the data: CJV QL YW YL JQ FG JL GFG. Contributed reagents/materials/analysis tools: EF JH JW HL HJ. Wrote the paper: CJV GFG.