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Research Article

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

  • Jennifer E. Griffin,

    Affiliation: Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Jeffrey D. Gawronski,

    Affiliation: Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Michael A. DeJesus,

    Affiliation: Department of Computer Science, Texas A&M University, College Station, Texas, United States of America

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  • Thomas R. Ioerger,

    Affiliation: Department of Computer Science, Texas A&M University, College Station, Texas, United States of America

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  • Brian J. Akerley,

    Affiliation: Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Christopher M. Sassetti mail

    Christopher.Sassetti@umassmed.edu

    Affiliations: Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.ppat.1002251

About the Authors

Jennifer E. Griffin, Jeffrey D. Gawronski, Brian J. Akerley, Christopher M. Sassetti
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Michael A. DeJesus, Thomas R. Ioerger
Department of Computer Science, Texas A&M University, College Station, Texas, United States of America
Christopher M. Sassetti
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Corresponding Author

Email: Christopher.Sassetti@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JEG CMS. Performed the experiments: JEG. Analyzed the data: JEG JDG MAD TRI CMS. Contributed reagents/materials/analysis tools: BJA. Wrote the paper: JEG CMS.