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Research Article

Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus Is Dependent on IL-6 and Intranasal Route of Infection

  • Thamotharampillai Dileepan equal contributor mail,

    equal contributor Contributed equally to this work with: Thamotharampillai Dileepan, Jonathan L. Linehan

    dile0003@umn.edu

    Affiliation: Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Jonathan L. Linehan equal contributor,

    equal contributor Contributed equally to this work with: Thamotharampillai Dileepan, Jonathan L. Linehan

    Affiliation: Department of Microbiology-Center for Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • James J. Moon,

    Affiliation: The Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America

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  • Marion Pepper,

    Affiliation: Department of Microbiology-Center for Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Marc K. Jenkins ,

    Affiliation: Department of Microbiology-Center for Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

    These authors are joint senior authors on this work.

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  • Patrick P. Cleary

    Affiliation: Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America

    These authors are joint senior authors on this work.

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  • Published: September 22, 2011
  • DOI: 10.1371/journal.ppat.1002252

About the Authors

Thamotharampillai Dileepan, Patrick P. Cleary
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America
Jonathan L. Linehan, Marion Pepper, Marc K. Jenkins
Department of Microbiology-Center for Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
James J. Moon
The Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: dile0003@umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TD JLL. Performed the experiments: TD JLL JJM MP. Analyzed the data: TD JLL. Contributed reagents/materials/analysis tools: JJM MKJ PPC. Wrote the paper: TD JLL MKJ PPC.