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Research Article

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

  • Selvakumar Subbian,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

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  • Liana Tsenova,

    Affiliations: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America, Biological Sciences Department, New York City College of Technology, Brooklyn, New York, United States of America

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  • Paul O'Brien,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

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  • Guibin Yang,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

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  • Mi-Sun Koo,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

    X
  • Blas Peixoto,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

    X
  • Dorothy Fallows,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

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  • Veronique Dartois,

    Affiliation: Novartis Institute for Tropical Diseases, Singapore

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  • George Muller,

    Affiliation: Celgene Corporation, Summit, New Jersey, United States of America

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  • Gilla Kaplan mail

    kaplangi@umdnj.edu

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America

    X
  • Published: September 15, 2011
  • DOI: 10.1371/journal.ppat.1002262

About the Authors

Selvakumar Subbian, Liana Tsenova, Paul O'Brien, Guibin Yang, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Gilla Kaplan
Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute (PHRI) at the University of Medicine and Dentistry of New Jersey (UMDNJ), Newark, New Jersey, United States of America
Liana Tsenova
Biological Sciences Department, New York City College of Technology, Brooklyn, New York, United States of America
Veronique Dartois
Novartis Institute for Tropical Diseases, Singapore
George Muller
Celgene Corporation, Summit, New Jersey, United States of America

Corresponding Author

Email: kaplangi@umdnj.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS DF LT GK. Performed the experiments: SS PO LT GY MK VD BP. Analyzed the data: SS GK. Contributed reagents/materials/analysis tools: VD GM. Wrote the paper: SS DF LT GK.