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Research Article

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

  • Maikel L. Colli,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Tatiane C. Nogueira,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Florent Allagnat,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Daniel A. Cunha,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Esteban N. Gurzov,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Alessandra K. Cardozo,

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Merja Roivainen,

    Affiliation: Intestinal Viruses Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland

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  • Anne Op de beeck,

    Affiliation: Virology Unit, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Decio L. Eizirik mail

    deizirik@ulb.ac.be

    Affiliation: Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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  • Published: September 22, 2011
  • DOI: 10.1371/journal.ppat.1002267

About the Authors

Maikel L. Colli, Tatiane C. Nogueira, Florent Allagnat, Daniel A. Cunha, Esteban N. Gurzov, Alessandra K. Cardozo, Decio L. Eizirik
Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium
Merja Roivainen
Intestinal Viruses Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland
Anne Op de beeck
Virology Unit, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

Corresponding Author

Email: deizirik@ulb.ac.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLC AOB DLE. Performed the experiments: MLC TCN AOB. Analyzed the data: MLC TCN AOB DLE. Contributed reagents/materials/analysis tools: FA DAC ENG AKC MR. Wrote the paper: MLC DLE.