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Research Article

Exhausted CD8 T Cells Downregulate the IL-18 Receptor and Become Unresponsive to Inflammatory Cytokines and Bacterial Co-infections

  • Jennifer T. Ingram,

    Affiliations: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • John S. Yi,

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    Current address: Division of Surgical Science, Duke University Medical Center, Durham, North Carolina, United States of America.

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  • Allan J. Zajac mail

    azajac@uab.edu

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.ppat.1002273

About the Authors

Jennifer T. Ingram
Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Jennifer T. Ingram, John S. Yi, Allan J. Zajac
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Corresponding Author

Email: azajac@uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTI AJZ. Performed the experiments: JTI JSY AJZ. Analyzed the data: JTI. Wrote the paper: JTI AJZ.