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Research Article

Multidrug Resistant 2009 A/H1N1 Influenza Clinical Isolate with a Neuraminidase I223R Mutation Retains Its Virulence and Transmissibility in Ferrets

  • Erhard van der Vries,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Edwin J. Veldhuis Kroeze,

    Affiliation: Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Koert J. Stittelaar,

    Affiliations: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands, Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Martin Linster,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Anne Van der Linden,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Eefje J. A. Schrauwen,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Lonneke M. Leijten,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Geert van Amerongen,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Martin Schutten,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Thijs Kuiken,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Albert D. M. E. Osterhaus,

    Affiliations: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands, Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Ron A. M. Fouchier,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Charles A. B. Boucher,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Sander Herfst mail

    s.herfst@erasmusmc.nl

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.ppat.1002276

About the Authors

Erhard van der Vries, Koert J. Stittelaar, Martin Linster, Anne Van der Linden, Eefje J. A. Schrauwen, Lonneke M. Leijten, Geert van Amerongen, Martin Schutten, Thijs Kuiken, Albert D. M. E. Osterhaus, Ron A. M. Fouchier, Charles A. B. Boucher, Sander Herfst
Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands
Edwin J. Veldhuis Kroeze, Koert J. Stittelaar, Albert D. M. E. Osterhaus
Viroclinics Biosciences BV, Rotterdam, The Netherlands

Corresponding Author

Email: s.herfst@erasmusmc.nl

Competing Interests

I have read the journal's policy and have the following conflicts. KJS, EJBVK, MS and ADMEO are employees of ViroClinics Biosciences BV. ADMEO is chief scientific officer of ViroClinics Biosciences BV. ADMEO, MS, EVDV and CABB participate in the IRIS study sponsored by Hoffmann-La Roche, Inc.

Author Contributions

Conceived and designed the experiments: EvdV EJVK KJS MS ADMEO RAMF CABB SH. Performed the experiments: EvdV EJVK KJS ML AvdL EJAS LML GvA. Analyzed the data: EvdV EJVK TK RAMF CABB SH. Contributed reagents/materials/analysis tools: MS CABB. Wrote the paper: EvdV EJVK TK RAMF CABB SH.