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Research Article

Evolutionarily Divergent, Unstable Filamentous Actin Is Essential for Gliding Motility in Apicomplexan Parasites

  • Kristen M. Skillman ,

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

    Contributed equally to the experimental studies.

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  • Karthikeyan Diraviyam ,

    Affiliation: Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan

    Contributed equally to the experimental studies.

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  • Asis Khan,

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

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  • Keliang Tang,

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

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  • David Sept ,

    Affiliation: Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan

    ‡ Contributed equally to the supervision of the studies.

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  • L. David Sibley mail

    sibley@borcim.wustl.edu

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

    ‡ Contributed equally to the supervision of the studies.

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.ppat.1002280

About the Authors

Kristen M. Skillman, Asis Khan, Keliang Tang, L. David Sibley
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri
Karthikeyan Diraviyam, David Sept
Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan

Corresponding Author

Email: sibley@borcim.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMS KD KT DS LDS. Performed the experiments: KMS KD KT. Analyzed the data: KMS KD AK DS LDS. Contributed reagents/materials/analysis tools: AK KT. Wrote the paper: KMS KD DS LDS.