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Research Article

HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

  • Gretja Schnell,

    Affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

    Current address: Department of Immunology, University of Washington, School of Medicine, Seattle, Washington, United States of America

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  • Sarah Joseph,

    Affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Serena Spudich,

    Affiliation: Department of Neurology, University of California at San Francisco, San Francisco, California, United States of America

    Current address: Department of Neurology, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Richard W. Price,

    Affiliation: Department of Neurology, University of California at San Francisco, San Francisco, California, United States of America

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  • Ronald Swanstrom mail

    risunc@med.unc.edu

    Affiliations: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.ppat.1002286

About the Authors

Gretja Schnell, Ronald Swanstrom
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America
Sarah Joseph, Ronald Swanstrom
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America
Serena Spudich, Richard W. Price
Department of Neurology, University of California at San Francisco, San Francisco, California, United States of America
Ronald Swanstrom
UNC Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: risunc@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS SJ SS RWP RS. Performed the experiments: GS. Analyzed the data: GS RS. Contributed reagents/materials/analysis tools: SS RWP RS. Wrote the paper: GS RS. Established the 293-Affinofile cell line in the laboratory: SJ. Analyzed the cellular surface expression of CD4 and CCR5: SJ. Designed the human study protocols: SS RWP.