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Research Article

The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

  • Glen P. Carter,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Gillian R. Douce,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Revathi Govind,

    Affiliation: Division of Biology, Kansas State University, Manhattan, Kansas, United States of America

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  • Pauline M. Howarth,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Kate E. Mackin,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Janice Spencer,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Anthony M. Buckley,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Ana Antunes,

    Affiliation: Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France

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  • Despina Kotsanas,

    Affiliation: Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia

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  • Grant A. Jenkin,

    Affiliation: Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia

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  • Bruno Dupuy,

    Affiliation: Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France

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  • Julian I. Rood,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Dena Lyras mail

    Dena.Lyras@monash.edu

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.ppat.1002317

About the Authors

Glen P. Carter, Pauline M. Howarth, Kate E. Mackin, Julian I. Rood, Dena Lyras
Department of Microbiology, Monash University, Clayton, Victoria, Australia
Gillian R. Douce, Janice Spencer, Anthony M. Buckley
Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
Revathi Govind
Division of Biology, Kansas State University, Manhattan, Kansas, United States of America
Ana Antunes, Bruno Dupuy
Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France
Despina Kotsanas, Grant A. Jenkin
Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia

Corresponding Author

Email: Dena.Lyras@monash.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GPC BD GAJ JIR GRD DL. Performed the experiments: GPC PMH KEM DK RG GRD JS AMB AA. Analyzed the data: GPC BD GAJ JIR PMH KEM DK RG AA GRD JS AMB DL. Contributed reagents/materials/analysis tools: GPC BD GAJ JIR DK RG GRD DL. Wrote the paper: GPC DL.