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Research Article

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

  • Scott W. Werneke equal contributor,

    equal contributor Contributed equally to this work with: Scott W. Werneke, Clementine Schilte, Matthew L. Albert, Deborah J. Lenschow

    Affiliation: Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Clementine Schilte equal contributor,

    equal contributor Contributed equally to this work with: Scott W. Werneke, Clementine Schilte, Matthew L. Albert, Deborah J. Lenschow

    Affiliations: Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France, INSERM U818, Paris, France

    X
  • Anjali Rohatgi,

    Affiliation: Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Kristen J. Monte,

    Affiliation: Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Alain Michault,

    Affiliation: Laboratoire de Microbiologie, Groupe Hospitalier Sud Réunion, Saint-Pierre, France

    X
  • Fernando Arenzana-Seisdedos,

    Affiliations: Unité de Pathogénie Virale Moléculaire, Institut Pasteur, Paris, France, CNRS URA 3015, Paris, France

    X
  • Dana L. Vanlandingham,

    Affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Stephen Higgs,

    Affiliation: Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, United States of America

    X
  • Arnaud Fontanet,

    Affiliation: Epidemiology of Emerging Infectious Diseases, Institut Pasteur, Paris, France

    X
  • Matthew L. Albert equal contributor mail,

    equal contributor Contributed equally to this work with: Scott W. Werneke, Clementine Schilte, Matthew L. Albert, Deborah J. Lenschow

    dlenscho@dom.wustl.edu (DJL); albertm@pasteur.fr (MLA)

    Affiliations: Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France, INSERM U818, Paris, France

    X
  • Deborah J. Lenschow equal contributor mail

    equal contributor Contributed equally to this work with: Scott W. Werneke, Clementine Schilte, Matthew L. Albert, Deborah J. Lenschow

    dlenscho@dom.wustl.edu (DJL); albertm@pasteur.fr (MLA)

    Affiliation: Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Published: October 20, 2011
  • DOI: 10.1371/journal.ppat.1002322

About the Authors

Scott W. Werneke, Anjali Rohatgi, Kristen J. Monte, Deborah J. Lenschow
Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Clementine Schilte, Matthew L. Albert
Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
Clementine Schilte, Matthew L. Albert
INSERM U818, Paris, France
Alain Michault
Laboratoire de Microbiologie, Groupe Hospitalier Sud Réunion, Saint-Pierre, France
Fernando Arenzana-Seisdedos
Unité de Pathogénie Virale Moléculaire, Institut Pasteur, Paris, France
Fernando Arenzana-Seisdedos
CNRS URA 3015, Paris, France
Dana L. Vanlandingham
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
Stephen Higgs
Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, United States of America
Arnaud Fontanet
Epidemiology of Emerging Infectious Diseases, Institut Pasteur, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJL MLA CS SWW. Performed the experiments: CS SWW AR KJM DJL. Analyzed the data: SWW CS DJL MLA AF FAS AM. Contributed reagents/materials/analysis tools: AM FAS SH DLV. Wrote the paper: SWW CS MLA DJL.