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Research Article

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

  • Susanne Pfefferle equal contributor,

    equal contributor Contributed equally to this work with: Susanne Pfefferle, Julia Schöpf, Manfred Kögl

    Affiliations: Bernhard-Nocht-Institute, Hamburg, Germany, Institute of Virology, University of Bonn, Bonn, Germany

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  • Julia Schöpf equal contributor,

    equal contributor Contributed equally to this work with: Susanne Pfefferle, Julia Schöpf, Manfred Kögl

    Affiliation: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany

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  • Manfred Kögl equal contributor,

    equal contributor Contributed equally to this work with: Susanne Pfefferle, Julia Schöpf, Manfred Kögl

    Affiliation: DKFZ, Heidelberg, Germany

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  • Caroline C. Friedel,

    Affiliations: Institute for Informatics, LMU Munich, München, Germany, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

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  • Marcel A. Müller,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Javier Carbajo-Lozoya,

    Affiliation: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany

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  • Thorsten Stellberger,

    Affiliation: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany

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  • Ekatarina von Dall’Armi,

    Affiliation: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany

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  • Petra Herzog,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Stefan Kallies,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Daniela Niemeyer,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Vanessa Ditt,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Thomas Kuri,

    Affiliation: IMMH, Albert-Ludwigs-University-Freiburg, Freiburg, Germany

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  • Roland Züst,

    Affiliation: Institute of Immunobiology, Kantonsspital St. Gallen, Switzerland

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  • Ksenia Pumpor,

    Affiliation: Institute of Biochemistry, University of Luebeck, Luebeck, Germany

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  • Rolf Hilgenfeld,

    Affiliation: Institute of Biochemistry, University of Luebeck, Luebeck, Germany

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  • Frank Schwarz,

    Affiliation: DKFZ, Heidelberg, Germany

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  • Ralf Zimmer,

    Affiliation: Institute for Informatics, LMU Munich, München, Germany

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  • Imke Steffen,

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Friedemann Weber,

    Affiliations: IMMH, Albert-Ludwigs-University-Freiburg, Freiburg, Germany, Institute of Virology, Philipps-Universität Marburg, Marburg, Germany

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  • Volker Thiel,

    Affiliation: Institute of Immunobiology, Kantonsspital St. Gallen, Switzerland

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  • Georg Herrler,

    Affiliation: Institute of Virology, Tierärztliche Hochschule Hannover, Hannover, Germany

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  • Heinz-Jürgen Thiel,

    Affiliation: Institute for Virology, Fachbereich Veterinärmedizin, Justus-Liebig Universität Gießen, Giessen, Germany

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  • Christel Schwegmann-Weßels,

    Affiliation: Institute of Virology, Tierärztliche Hochschule Hannover, Hannover, Germany

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  • Stefan Pöhlmann,

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Jürgen Haas mail,

    vonbrunn@mvp.uni-muenchen.de (AvB); drosten@virology-bonn.de (CD); juergen.haas@ed.ac.uk (JH)

    Affiliations: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany, Division of Pathway Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Christian Drosten mail,

    vonbrunn@mvp.uni-muenchen.de (AvB); drosten@virology-bonn.de (CD); juergen.haas@ed.ac.uk (JH)

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Albrecht von Brunn mail

    vonbrunn@mvp.uni-muenchen.de (AvB); drosten@virology-bonn.de (CD); juergen.haas@ed.ac.uk (JH)

    Affiliation: Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany

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  • Published: October 27, 2011
  • DOI: 10.1371/journal.ppat.1002331

About the Authors

Susanne Pfefferle
Bernhard-Nocht-Institute, Hamburg, Germany
Susanne Pfefferle, Marcel A. Müller, Petra Herzog, Stefan Kallies, Daniela Niemeyer, Vanessa Ditt, Christian Drosten
Institute of Virology, University of Bonn, Bonn, Germany
Julia Schöpf, Javier Carbajo-Lozoya, Thorsten Stellberger, Ekatarina von Dall’Armi, Jürgen Haas, Albrecht von Brunn
Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich, München, Germany
Manfred Kögl, Frank Schwarz
DKFZ, Heidelberg, Germany
Caroline C. Friedel, Ralf Zimmer
Institute for Informatics, LMU Munich, München, Germany
Caroline C. Friedel
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany
Thomas Kuri, Friedemann Weber
IMMH, Albert-Ludwigs-University-Freiburg, Freiburg, Germany
Roland Züst, Volker Thiel
Institute of Immunobiology, Kantonsspital St. Gallen, Switzerland
Ksenia Pumpor, Rolf Hilgenfeld
Institute of Biochemistry, University of Luebeck, Luebeck, Germany
Imke Steffen, Stefan Pöhlmann
Institute of Virology, Hannover Medical School, Hannover, Germany
Friedemann Weber
Institute of Virology, Philipps-Universität Marburg, Marburg, Germany
Georg Herrler, Christel Schwegmann-Weßels
Institute of Virology, Tierärztliche Hochschule Hannover, Hannover, Germany
Heinz-Jürgen Thiel
Institute for Virology, Fachbereich Veterinärmedizin, Justus-Liebig Universität Gießen, Giessen, Germany
Jürgen Haas
Division of Pathway Medicine, University of Edinburgh, Edinburgh, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M. Kögl, F. Weber, V. Thiel, G. Herrler, H. Thiel, C. Swegmann-Weßels, S. Pöhlmann, C. Drosten, A. von Brunn. Performed the experiments: S. Pfefferle, J. Schöpf, M. Müller, J. Carbajo-Lozoya, T. Stellberger, P. Herzong, S. Kallies, D. Niemeyer, V. Ditt, T. Kuri, R. Züst, E. von Dall'Armi, I. Steffen, A. von Brunn. Analyzed the data: M. Kögl, C. Friedel, R. Zimmer, F. Schwarz, F. Weber, V. Thiel, H. Thiel, C. Schwegmann-Weßels, S. Pöhlmann, C. Drosten, A. von Brunn. Contributed reagents/materials/analysis tools: K. Pumpor, R. Hilgenfeld, J. Haas. Wrote the paper: A. von Brunn, C. Drosten, S. Pöhlmann.