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Research Article

The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection

  • Toshihiro Ito,

    Affiliations: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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  • Ronald M. Allen,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • William F. Carson IV,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Matthew Schaller,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Karen A. Cavassani,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Cory M. Hogaboam,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Nicholas W. Lukacs,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Akihiro Matsukawa,

    Affiliation: Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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  • Steven L. Kunkel mail

    slkunkel@umich.edu

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.ppat.1002341

About the Authors

Toshihiro Ito, Ronald M. Allen, William F. Carson IV, Matthew Schaller, Karen A. Cavassani, Cory M. Hogaboam, Nicholas W. Lukacs, Steven L. Kunkel
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Toshihiro Ito, Akihiro Matsukawa
Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Corresponding Author

Email: slkunkel@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TI KAC CMH NWL AM SLK. Performed the experiments: TI RMA. Analyzed the data: TI. Contributed reagents/materials/analysis tools: TI WFC MS. Wrote the paper: TI SLK.