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Research Article

Fatal Prion Disease in a Mouse Model of Genetic E200K Creutzfeldt-Jakob Disease

  • Yael Friedman-Levi,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Zeev Meiner,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Tamar Canello,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Kati Frid,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Gabor G. Kovacs,

    Affiliation: Institute of Neurology, Medical University Vienna, Austria

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  • Herbert Budka,

    Affiliation: Institute of Neurology, Medical University Vienna, Austria

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  • Dana Avrahami,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Ruth Gabizon mail

    gabizonr@hadassah.org.il

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.ppat.1002350

About the Authors

Yael Friedman-Levi, Zeev Meiner, Tamar Canello, Kati Frid, Dana Avrahami, Ruth Gabizon
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
Gabor G. Kovacs, Herbert Budka
Institute of Neurology, Medical University Vienna, Austria

Corresponding Author

Email: gabizonr@hadassah.org.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YFL ZM GGK HB DA RG. Performed the experiments: TC KF YFL GGK DA RG. Analyzed the data: GGK HB ZM RG YFL. Contributed reagents/materials/analysis tools: ZM GGK TC. Wrote the paper: YFL GGK RG HB.