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Research Article

A Receptor-based Switch that Regulates Anthrax Toxin Pore Formation

  • Rosemarie M. Pilpa,

    Affiliation: Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Monika Bayrhuber,

    Affiliations: Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • John M. Marlett,

    Affiliation: Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Roland Riek mail,

    jyoung@salk.edu (JATY); roland.riek@phys.chem.ethz.ch (RR)

    Affiliations: Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • John A. T. Young mail

    jyoung@salk.edu (JATY); roland.riek@phys.chem.ethz.ch (RR)

    Affiliation: Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.ppat.1002354

About the Authors

Rosemarie M. Pilpa, John M. Marlett, John A. T. Young
Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, California, United States of America
Monika Bayrhuber, Roland Riek
Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
Monika Bayrhuber, Roland Riek
Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMP MB RR JATY. Performed the experiments: RMP JMM. Analyzed the data: RMP RR JATY. Contributed reagents/materials/analysis tools: MB RR. Wrote the paper: RMP RR JATY.