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Research Article

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

  • Bjoern F. Kraemer equal contributor,

    equal contributor Contributed equally to this work with: Bjoern F. Kraemer, Robert A. Campbell, Andrew S. Weyrich

    Affiliations: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America, Medizinische Klinik III, Universitaetsklinikum Tuebingen, Tuebingen, Germany

    X
  • Robert A. Campbell equal contributor,

    equal contributor Contributed equally to this work with: Bjoern F. Kraemer, Robert A. Campbell, Andrew S. Weyrich

    Affiliation: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Hansjörg Schwertz,

    Affiliations: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America, Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Mark J. Cody,

    Affiliation: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Zechariah Franks,

    Affiliation: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Neal D. Tolley,

    Affiliation: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Walter H. A. Kahr,

    Affiliation: Division of Haematology/Oncology, Program in Cell Biology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada

    X
  • Stephan Lindemann,

    Affiliation: The Petri-Hospital, Warburg, Germany

    X
  • Peter Seizer,

    Affiliation: Medizinische Klinik III, Universitaetsklinikum Tuebingen, Tuebingen, Germany

    X
  • Christian C. Yost,

    Affiliations: Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Guy A. Zimmerman,

    Affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Andrew S. Weyrich equal contributor mail

    equal contributor Contributed equally to this work with: Bjoern F. Kraemer, Robert A. Campbell, Andrew S. Weyrich

    andy.weyrich@u2m2.utah.edu

    Affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Published: November 10, 2011
  • DOI: 10.1371/journal.ppat.1002355

About the Authors

Bjoern F. Kraemer, Robert A. Campbell, Hansjörg Schwertz, Mark J. Cody, Zechariah Franks, Neal D. Tolley, Christian C. Yost
Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States of America
Bjoern F. Kraemer, Peter Seizer
Medizinische Klinik III, Universitaetsklinikum Tuebingen, Tuebingen, Germany
Hansjörg Schwertz
Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America
Walter H. A. Kahr
Division of Haematology/Oncology, Program in Cell Biology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Stephan Lindemann
The Petri-Hospital, Warburg, Germany
Christian C. Yost
Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America
Guy A. Zimmerman, Andrew S. Weyrich
Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America

Corresponding Author

Email: andy.weyrich@u2m2.utah.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BFK RAC HS NDT SL PS GAZ ASW. Performed the experiments: BFK RAC HS MJC ZF WHAK. Analyzed the data: BFK RAC HS MJC ZF CCY GAZ ASW. Contributed reagents/materials/analysis tools: NDT WHAK. Wrote the paper: BFK RAC ASW.