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Research Article

Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

  • Benjamin P. Howden mail,

    Benjamin.Howden@austin.org.au

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Microbiology Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Christopher R. E. McEvoy,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • David L. Allen,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Kyra Chua,

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Wei Gao,

    Affiliations: Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Paul F. Harrison,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Jan Bell,

    Affiliation: SA Pathology, Womens and Children’s Hospital, Adelaide, South Australia, Australia

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  • Geoffrey Coombs,

    Affiliation: Microbiology Department, Royal Perth Hospital, Perth, Western Australia, Australia

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  • Vicki Bennett-Wood,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • Jessica L. Porter,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • Roy Robins-Browne,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • John K. Davies,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Timothy P. Stinear

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: November 10, 2011
  • DOI: 10.1371/journal.ppat.1002359

About the Authors

Benjamin P. Howden, Christopher R. E. McEvoy, Kyra Chua, Vicki Bennett-Wood, Jessica L. Porter, Roy Robins-Browne, Timothy P. Stinear
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Benjamin P. Howden, Wei Gao
Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
Benjamin P. Howden
Microbiology Department, Austin Health, Heidelberg, Victoria, Australia
Benjamin P. Howden, David L. Allen, Kyra Chua, Wei Gao, John K. Davies, Timothy P. Stinear
Department of Microbiology, Monash University, Clayton, Victoria, Australia
Paul F. Harrison, Torsten Seemann
Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia
Jan Bell
SA Pathology, Womens and Children’s Hospital, Adelaide, South Australia, Australia
Geoffrey Coombs
Microbiology Department, Royal Perth Hospital, Perth, Western Australia, Australia

Corresponding Author

Email: Benjamin.Howden@austin.org.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BPH TPS JKD. Performed the experiments: BPH CREM DLA KC WG JB GC VBW JLP. Analyzed the data: BPH PFH TS TPS CREM RRB JKD. Contributed reagents/materials/analysis tools: RRB PFH TS. Wrote the paper: BPH CREM TPS. Designed software used for analysis: TS PFH.