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Research Article

Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner

  • Camile P. Semighini,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Anna F. Averette,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • John R. Perfect,

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Joseph Heitman mail

    heitm001@duke.edu

    Affiliations: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: November 17, 2011
  • DOI: 10.1371/journal.ppat.1002364

About the Authors

Camile P. Semighini, Anna F. Averette, John R. Perfect, Joseph Heitman
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
John R. Perfect, Joseph Heitman
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Joseph Heitman
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: heitm001@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CPS JRP JH. Performed the experiments: CPS AFA. Analyzed the data: CPS JRP JH. Contributed reagents/materials/analysis tools: JRP JH. Wrote the paper: CPS JH. Manuscript edits: AFA JRP.