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Research Article

Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent Replication

  • Subhash C. Verma mail,

    scverma@medicine.nevada.edu (SCV); erle@mail.med.upenn.edu (ESR); carl.schildkraut@einstein.yu.edu (CLS)

    Affiliation: Department of Microbiology & Immunology, University of Nevada, Reno, School of Medicine, Center for Molecular Medicine, Reno, Nevada, United States of America

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  • Jie Lu,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Qiliang Cai,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Settapong Kosiyatrakul,

    Affiliation: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Maria E. McDowell,

    Affiliation: Department of Microbiology & Immunology, University of Nevada, Reno, School of Medicine, Center for Molecular Medicine, Reno, Nevada, United States of America

    X
  • Carl L. Schildkraut mail,

    scverma@medicine.nevada.edu (SCV); erle@mail.med.upenn.edu (ESR); carl.schildkraut@einstein.yu.edu (CLS)

    Affiliation: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

    X
  • Erle S. Robertson mail

    scverma@medicine.nevada.edu (SCV); erle@mail.med.upenn.edu (ESR); carl.schildkraut@einstein.yu.edu (CLS)

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.ppat.1002365

About the Authors

Subhash C. Verma, Maria E. McDowell
Department of Microbiology & Immunology, University of Nevada, Reno, School of Medicine, Center for Molecular Medicine, Reno, Nevada, United States of America
Jie Lu, Qiliang Cai, Erle S. Robertson
Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Settapong Kosiyatrakul, Carl L. Schildkraut
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SCV ESR. Performed the experiments: SCV QC JL MEM. Analyzed the data: SCV SK CLS ESR. Contributed reagents/materials/analysis tools: SCV CLS ESR. Wrote the paper: SCV CLS ESR.