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Research Article

The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces

  • Edmond Wong,

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

    Current address: Division of Molecular Structure, The National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Gustav Vaaje-Kolstad,

    Affiliation: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway

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  • Avishek Ghosh,

    Affiliation: Division of Biochemistry, National Institute of Cholera and Enteric Diseases, Scheme XM, Beliaghata, Kolkata, India

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  • Ramon Hurtado-Guerrero,

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

    Current address: Institute for Biocomputation and Physics of Complex Systems, University of Zaragoza, Zaragoza, Spain

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  • Peter V. Konarev,

    Affiliation: European Molecular Biology Laboratory (EMBL), Outstation Hamburg at DESY, Hamburg, Germany

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  • Adel F. M. Ibrahim,

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Dmitri I. Svergun,

    Affiliation: European Molecular Biology Laboratory (EMBL), Outstation Hamburg at DESY, Hamburg, Germany

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  • Vincent G. H. Eijsink,

    Affiliation: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway

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  • Nabendu S. Chatterjee,

    Affiliation: Division of Biochemistry, National Institute of Cholera and Enteric Diseases, Scheme XM, Beliaghata, Kolkata, India

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  • Daan M. F. van Aalten mail

    dmfvanaalten@dundee.ac.uk

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Published: January 12, 2012
  • DOI: 10.1371/journal.ppat.1002373

About the Authors

Edmond Wong, Ramon Hurtado-Guerrero, Adel F. M. Ibrahim, Daan M. F. van Aalten
Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
Gustav Vaaje-Kolstad, Vincent G. H. Eijsink
Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway
Avishek Ghosh, Nabendu S. Chatterjee
Division of Biochemistry, National Institute of Cholera and Enteric Diseases, Scheme XM, Beliaghata, Kolkata, India
Peter V. Konarev, Dmitri I. Svergun
European Molecular Biology Laboratory (EMBL), Outstation Hamburg at DESY, Hamburg, Germany

Corresponding Author

Email: dmfvanaalten@dundee.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EW GVK RHG DMFvA NSC VGHE. Performed the experiments: EW GVK AG PVK AFMI DMFvA. Analyzed the data: EW GVK AG RHG PVK DIS VGHE NSC DMFvA. Wrote the paper: EW DIS VGHE NSC DMFvA.