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Research Article

A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis

  • Alexander W. Beham equal contributor mail,

    equal contributor Contributed equally to this work with: Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs

    abeham@chirurgie-goettingen.de (AWB); wolfgang.kaminski@umm.de (WEK)

    Affiliation: Department of Surgery, University of Göttingen, Göttingen, Germany

    X
  • Kerstin Puellmann equal contributor,

    equal contributor Contributed equally to this work with: Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs

    Affiliation: Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany

    X
  • Rebecca Laird equal contributor,

    equal contributor Contributed equally to this work with: Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs

    Affiliation: Department of Surgery, University of Göttingen, Göttingen, Germany

    X
  • Tina Fuchs equal contributor,

    equal contributor Contributed equally to this work with: Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

    X
  • Roswita Streich,

    Affiliation: Department of Surgery, University of Göttingen, Göttingen, Germany

    X
  • Caroline Breysach,

    Affiliation: Department of Surgery, University of Göttingen, Göttingen, Germany

    X
  • Dirk Raddatz,

    Affiliation: Department of Medicine, University of Göttingen, Göttingen, Germany

    X
  • Septimia Oniga,

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

    X
  • Teresa Peccerella,

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

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  • Peter Findeisen,

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

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  • Julia Kzhyshkowska,

    Affiliations: Department of Dermatology, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

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  • Alexei Gratchev,

    Affiliations: Department of Dermatology, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

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  • Stefan Schweyer,

    Affiliation: Department of Pathology, University of Göttingen, Göttingen, Germany

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  • Bernadette Saunders,

    Affiliation: Medicine, Central Clinical School, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia

    X
  • Johannes T. Wessels,

    Affiliation: Department of Nephrology/Rheumatology, University of Göttingen, Göttingen, Germany

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  • Wiebke Möbius,

    Affiliations: Max-Planck-Institute of Experimental Medicine, Department of Neurogenetics, Göttingen, Germany, Trinity College Dublin, Institute of Molecular Medicine, College Green, Dublin, Ireland

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  • Joseph Keane,

    Affiliation: Trinity College Dublin, Institute of Molecular Medicine, College Green, Dublin, Ireland

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  • Heinz Becker,

    Affiliation: Department of Surgery, University of Göttingen, Göttingen, Germany

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  • Arnold Ganser,

    Affiliation: Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany

    X
  • Michael Neumaier,

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

    X
  • Wolfgang E. Kaminski mail

    abeham@chirurgie-goettingen.de (AWB); wolfgang.kaminski@umm.de (WEK)

    Affiliation: Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany

    X
  • Published: November 17, 2011
  • DOI: 10.1371/journal.ppat.1002375

About the Authors

Alexander W. Beham, Rebecca Laird, Roswita Streich, Caroline Breysach, Heinz Becker
Department of Surgery, University of Göttingen, Göttingen, Germany
Kerstin Puellmann, Arnold Ganser
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
Tina Fuchs, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Michael Neumaier, Wolfgang E. Kaminski
Institute for Clinical Chemistry, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany
Dirk Raddatz
Department of Medicine, University of Göttingen, Göttingen, Germany
Julia Kzhyshkowska, Alexei Gratchev
Department of Dermatology, University of Heidelberg Medical Faculty Mannheim, Mannheim, Germany
Julia Kzhyshkowska, Alexei Gratchev
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
Stefan Schweyer
Department of Pathology, University of Göttingen, Göttingen, Germany
Bernadette Saunders
Medicine, Central Clinical School, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
Johannes T. Wessels
Department of Nephrology/Rheumatology, University of Göttingen, Göttingen, Germany
Wiebke Möbius
Max-Planck-Institute of Experimental Medicine, Department of Neurogenetics, Göttingen, Germany
Wiebke Möbius, Joseph Keane
Trinity College Dublin, Institute of Molecular Medicine, College Green, Dublin, Ireland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AW. Beham, K. Puellmann, R. Laird, T. Fuchs, S. Oniga, T. Peccerella, P. Findeisen, J. Kzhyshkowska, A. Gratchev, B. Saunders, JT. Wessels, W. Möbius, WE. Kaminski. Performed the experiments: AW. Beham, K. Puellmann, R. Laird, T. Fuchs, R. Streich, C. Breysach, S. Oniga, T. Peccerella, P. Findeisen, J. Kzhyshkowska, A. Gratchev, S. Schweyer, B. Saunders, JT. Wessels, W. Möbius, WE. Kaminski. Analyzed the data: AW. Beham, K. Puellmann, R. Laird, T. Fuchs, S. Oniga, T. Peccerella, P. Findeisen, J. Kzhyshkowska, A. Gratchev, B. Saunders, J. Wessels, W. Möbius, J. Keane, H. Becker, A. Ganser, M. Neumaier, WE. Kaminski. Contributed reagents/materials/analysis tools: D. Raddatz, J. Keane, B. Saunders. Wrote the paper: AW. Beham, K. Puellmann, WE. Kaminski.