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Research Article

UDP-glucose 4, 6-dehydratase Activity Plays an Important Role in Maintaining Cell Wall Integrity and Virulence of Candida albicans

  • Manimala Sen,

    Affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

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  • Bhavin Shah,

    Affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

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  • Srabanti Rakshit,

    Affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore, India

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  • Vijender Singh,

    Affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

    Current address: Wellcome Trust Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Bhavna Padmanabhan,

    Affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

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  • Manikandan Ponnusamy,

    Affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore, India

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  • Koteppa Pari,

    Affiliation: Piramal Life Sciences India Ltd., Mumbai, India

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  • Ram Vishwakarma,

    Affiliation: Piramal Life Sciences India Ltd., Mumbai, India

    Current address: Indian Institute of Integrative Medicine, Canal Road, Jammu–Tawi, India

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  • Dipankar Nandi,

    Affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore, India

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  • Parag P. Sadhale mail

    pps@mcbl.iisc.ernet.in

    Affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

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  • Published: November 17, 2011
  • DOI: 10.1371/journal.ppat.1002384

About the Authors

Manimala Sen, Bhavin Shah, Vijender Singh, Bhavna Padmanabhan, Parag P. Sadhale
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
Srabanti Rakshit, Manikandan Ponnusamy, Dipankar Nandi
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Koteppa Pari, Ram Vishwakarma
Piramal Life Sciences India Ltd., Mumbai, India

Corresponding Author

Email: pps@mcbl.iisc.ernet.in

Competing Interests

Piramal Life Sciences Ltd. provided financial support for this study, and authors Pari and Vishwakarma are full-time employees of the company.

Author Contributions

Conceived and designed the experiments: PPS DN RV. Performed the experiments: MS BS SR VS BP MP KP. Analyzed the data: KP RV DN PPS. Wrote the paper: PPS DN KP.