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Research Article

Acquisition of Pneumococci Specific Effector and Regulatory Cd4+ T Cells Localising within Human Upper Respiratory-Tract Mucosal Lymphoid Tissue

  • Jeffrey Pido-Lopez,

    Affiliation: School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

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  • William W. Kwok,

    Affiliation: Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America

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  • Timothy J. Mitchell,

    Affiliation: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

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  • Robert S. Heyderman,

    Affiliation: Wellcome Trust Clinical Research Programme, Blantyre, Malawi

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  • Neil A. Williams mail

    neil.a.williams@bristol.ac.uk

    Affiliation: School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

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  • Published: December 01, 2011
  • DOI: 10.1371/journal.ppat.1002396

About the Authors

Jeffrey Pido-Lopez, Neil A. Williams
School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
William W. Kwok
Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America
Timothy J. Mitchell
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Robert S. Heyderman
Wellcome Trust Clinical Research Programme, Blantyre, Malawi

Corresponding Author

Email: neil.a.williams@bristol.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAW RSH WWK JP-L. Performed the experiments: JP-L TJM WWK. Analyzed the data: NAW RSH WWK JP-L TJM. Contributed reagents/materials/analysis tools: WWK TJM. Wrote the paper: JP-L NAW RSH.