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Research Article

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

  • Rebecca M. DuBois equal contributor,

    equal contributor Contributed equally to this work with: Rebecca M. DuBois, Hassan Zaraket

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee United States of America, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Hassan Zaraket equal contributor,

    equal contributor Contributed equally to this work with: Rebecca M. DuBois, Hassan Zaraket

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Muralidhar Reddivari,

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Richard J. Heath,

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Stephen W. White,

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee United States of America, Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

    X
  • Charles J. Russell mail

    charles.russell@stjude.org

    Affiliations: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

    X
  • Published: December 01, 2011
  • DOI: 10.1371/journal.ppat.1002398

About the Authors

Rebecca M. DuBois, Stephen W. White
Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee United States of America
Rebecca M. DuBois, Hassan Zaraket, Muralidhar Reddivari, Richard J. Heath, Charles J. Russell
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Stephen W. White, Charles J. Russell
Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Corresponding Author

Email: charles.russell@stjude.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HZ, RMD, SWW, CJR. Performed the experiments: HZ RMD. Analyzed the data: HZ RMD SWW CJR. Contributed reagents/materials/analysis tools: MR RJH. Wrote the paper: HZ RMD SWW CJR.