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Research Article

Cryo Electron Tomography of Herpes Simplex Virus during Axonal Transport and Secondary Envelopment in Primary Neurons

  • Iosune Ibiricu,

    Affiliation: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Juha T. Huiskonen,

    Affiliations: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany, Institute of Biotechnology, University of Helsinki, Helsinki, Finland, Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Katinka Döhner,

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Frank Bradke,

    Affiliations: Research Group Axonal Growth and Regeneration, Max Planck Institute of Neurobiology, Martinsried, Germany, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

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  • Beate Sodeik,

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Kay Grünewald mail

    kay@strubi.ox.ac.uk

    Affiliations: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany, Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.ppat.1002406

About the Authors

Iosune Ibiricu, Juha T. Huiskonen, Kay Grünewald
Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
Juha T. Huiskonen
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Juha T. Huiskonen, Kay Grünewald
Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Katinka Döhner, Beate Sodeik
Institute of Virology, Hannover Medical School, Hannover, Germany
Frank Bradke
Research Group Axonal Growth and Regeneration, Max Planck Institute of Neurobiology, Martinsried, Germany
Frank Bradke
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

Corresponding Author

Email: kay@strubi.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: II JTH KG. Performed the experiments: II JTH KG. Analyzed the data: II JTH KG. Contributed reagents/materials/analysis tools: II JTH KD FB BS KG. Wrote the paper: II JTH KD FB BS KG.