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Research Article

A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection

  • Amelia K. Pinto,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Stephane Daffis,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    Current address: Gilead Sciences, Foster City, California, United States of America.

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  • James D. Brien,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Maria D. Gainey,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Wayne M. Yokoyama,

    Affiliations: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Kathleen C. F. Sheehan,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Kenneth M. Murphy,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Robert D. Schreiber,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael S. Diamond mail

    diamond@borcim.wustl.edu

    Affiliations: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: December 01, 2011
  • DOI: 10.1371/journal.ppat.1002407

About the Authors

Amelia K. Pinto, Stephane Daffis, James D. Brien, Maria D. Gainey, Wayne M. Yokoyama, Michael S. Diamond
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
Wayne M. Yokoyama, Kathleen C. F. Sheehan, Kenneth M. Murphy, Robert D. Schreiber, Michael S. Diamond
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Michael S. Diamond
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: diamond@borcim.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKP SD JDB MDG MSD. Performed the experiments: AKP SD JDB. Analyzed the data: AKP SD JDB. Contributed reagents/materials/analysis tools: WMY KMM KCFS RDS. Wrote the paper: AKP SD JDB MDG WMY KCFS KMM RDS MSD.