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Research Article

Sialidases Affect the Host Cell Adherence and Epsilon Toxin-Induced Cytotoxicity of Clostridium perfringens Type D Strain CN3718

  • Jihong Li,

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Sameera Sayeed,

    Affiliation: Department of Environmental and Occupational Health, University of Pittsburgh, Pennsylvania, United States of America

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  • Susan Robertson,

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Jianming Chen,

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Bruce A. McClane mail

    bamcc@pitt.edu

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.ppat.1002429

About the Authors

Jihong Li, Susan Robertson, Jianming Chen, Bruce A. McClane
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Sameera Sayeed
Department of Environmental and Occupational Health, University of Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: bamcc@pitt.edu

Competing Interests

The authors have declared that no competing issues exist.

Author Contributions

Conceived and designed the experiments: JL SS BAM SR. Performed the experiments: JL SS SR JC. Analyzed the data: JL SR BAM. Wrote the paper: JL BAM.