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Research Article

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

  • Carlos Maluquer de Motes,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Samantha Cooray equal contributor,

    equal contributor Contributed equally to this work with: Samantha Cooray, Hongwei Ren

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom

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  • Hongwei Ren equal contributor,

    equal contributor Contributed equally to this work with: Samantha Cooray, Hongwei Ren

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Gabriel M. F. Almeida,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

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  • Kieran McGourty,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom

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  • Mohammad W. Bahar,

    Affiliation: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • David I. Stuart,

    Affiliations: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Science Division, Diamond Light Source, Didcot, United Kingdom

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  • Jonathan M. Grimes,

    Affiliations: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Science Division, Diamond Light Source, Didcot, United Kingdom

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  • Stephen C. Graham,

    Affiliation: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    Current address: Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Geoffrey L. Smith mail

    geoffrey.l.smith@imperial.ac.uk

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.ppat.1002430

About the Authors

Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel M. F. Almeida, Kieran McGourty, Geoffrey L. Smith
Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom
Mohammad W. Bahar, David I. Stuart, Jonathan M. Grimes, Stephen C. Graham
The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
David I. Stuart, Jonathan M. Grimes
Science Division, Diamond Light Source, Didcot, United Kingdom

Corresponding Author

Email: geoffrey.l.smith@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CM SC HR MWB DIS JMG SCG GLS. Performed the experiments: CM SC HR GMFA KM MWB SCG. Analyzed the data: CM SC HR MWB DIS JMG SCG GLS. Wrote the paper: CM SC DIS JMG SCG GLS.