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Research Article

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

  • Cheng Huang,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Kumari G. Lokugamage,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Janet M. Rozovics,

    Affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America

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  • Krishna Narayanan,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Bert L. Semler,

    Affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America

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  • Shinji Makino mail

    shmakino@utmb.edu

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.ppat.1002433

About the Authors

Cheng Huang, Kumari G. Lokugamage, Krishna Narayanan, Shinji Makino
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
Janet M. Rozovics, Bert L. Semler
Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America

Corresponding Author

Email: shmakino@utmb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CH SM. Performed the experiments: CH KGL KN. Analyzed the data: CH KGL KN SM. Contributed reagents/materials/analysis tools: JMR BLS. Wrote the paper: CH KN BLS SM.