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Research Article

Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy

  • Ming Zeng,

    Affiliation: Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Peter J. Southern,

    Affiliation: Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Cavan S. Reilly,

    Affiliation: Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Greg J. Beilman,

    Affiliation: Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Jeffrey G. Chipman,

    Affiliation: Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Timothy W. Schacker,

    Affiliation: Department of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Ashley T. Haase mail

    haase001@umn.edu

    Affiliation: Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Published: January 05, 2012
  • DOI: 10.1371/journal.ppat.1002437

About the Authors

Ming Zeng, Peter J. Southern, Ashley T. Haase
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
Cavan S. Reilly
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
Greg J. Beilman, Jeffrey G. Chipman
Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
Timothy W. Schacker
Department of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: haase001@umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MZ TWS ATH. Performed the experiments: MZ PJS. Analyzed the data: MZ CSR. Contributed reagents/materials/analysis tools: TWS GJB JGC. Wrote the paper: MZ ATH.