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Research Article

Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3

  • Marcelo Marcet-Palacios,

    Affiliation: University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada

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  • Brenda Lee Duggan,

    Affiliation: University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada

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  • Irene Shostak,

    Affiliation: University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada

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  • Michele Barry,

    Affiliation: University of Alberta, Department of Medical Microbiology and Immunology, Edmonton, Alberta, Canada

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  • Tracy Geskes,

    Affiliation: University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada

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  • John A. Wilkins,

    Affiliation: University of Manitoba, Manitoba Centre for Proteomics & Systems Biology, Winnipeg, Manitoba, Canada

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  • Akiko Yanagiya,

    Affiliation: McGill University, Department of Biochemistry, Montreal, Quebec, Canada

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  • Nahum Sonenberg,

    Affiliation: McGill University, Department of Biochemistry, Montreal, Quebec, Canada

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  • R. Chris Bleackley mail

    chris.bleackley@ualberta.ca

    Affiliation: University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.ppat.1002447

About the Authors

Marcelo Marcet-Palacios, Brenda Lee Duggan, Irene Shostak, Tracy Geskes, R. Chris Bleackley
University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada
Michele Barry
University of Alberta, Department of Medical Microbiology and Immunology, Edmonton, Alberta, Canada
John A. Wilkins
University of Manitoba, Manitoba Centre for Proteomics & Systems Biology, Winnipeg, Manitoba, Canada
Akiko Yanagiya, Nahum Sonenberg
McGill University, Department of Biochemistry, Montreal, Quebec, Canada

Corresponding Author

Email: chris.bleackley@ualberta.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMP RCB MB IS BLD. Performed the experiments: MMP BLD IS TG MB JAW. Analyzed the data: MMP BLD MB. Contributed reagents/materials/analysis tools: AY NS MB. Wrote the paper: MMP.