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Research Article

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

  • Ivonne Ceballos-Olvera,

    Affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Manoranjan Sahoo,

    Affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Mark A. Miller,

    Affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Laura del Barrio,

    Affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Fabio Re mail

    fre@uthsc.edu; fabio.re@rosalindfranklin.edu

    Affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Published: December 29, 2011
  • DOI: 10.1371/journal.ppat.1002452

About the Authors

Ivonne Ceballos-Olvera, Manoranjan Sahoo, Mark A. Miller, Laura del Barrio, Fabio Re
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Corresponding Author

Email: fre@uthsc.edu fabio.re@rosalindfranklin.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FR. Performed the experiments: ICO MS MAM LdB FR. Analyzed the data: ICO MS MAM LdB FR. Wrote the paper: FR.