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Research Article

CNS Recruitment of CD8+ T Lymphocytes Specific for a Peripheral Virus Infection Triggers Neuropathogenesis during Polymicrobial Challenge

  • Christine M. Matullo,

    Affiliations: Fox Chase Cancer Center, Division of Basic Science, Program in Immune Cell Development and Host Defense, Philadelphia, Pennsylvania, United States of America, Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania, United States of America

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  • Kevin J. O'Regan,

    Affiliation: Fox Chase Cancer Center, Division of Basic Science, Program in Immune Cell Development and Host Defense, Philadelphia, Pennsylvania, United States of America

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  • Mark Curtis,

    Affiliation: Thomas Jefferson University, Department of Pathology, Anatomy, and Cell Biology, Philadelphia, Pennsylvania, United States of America

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  • Glenn F. Rall mail

    glenn.rall@fccc.edu

    Affiliation: Fox Chase Cancer Center, Division of Basic Science, Program in Immune Cell Development and Host Defense, Philadelphia, Pennsylvania, United States of America

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  • Published: December 22, 2011
  • DOI: 10.1371/journal.ppat.1002462

About the Authors

Christine M. Matullo, Kevin J. O'Regan, Glenn F. Rall
Fox Chase Cancer Center, Division of Basic Science, Program in Immune Cell Development and Host Defense, Philadelphia, Pennsylvania, United States of America
Christine M. Matullo
Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania, United States of America
Mark Curtis
Thomas Jefferson University, Department of Pathology, Anatomy, and Cell Biology, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: glenn.rall@fccc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMM KJO'R GFR. Performed the experiments: CMM KJO'R. Analyzed the data: CMM KJO'R MC GFR. Contributed reagents/materials/analysis tools: MC GFR. Wrote the paper: CMM KJO'R GFR.