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Research Article

Allelic Variation on Murine Chromosome 11 Modifies Host Inflammatory Responses and Resistance to Bacillus anthracis

  • Jill K. Terra,

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Bryan France,

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Christopher K. Cote,

    Affiliation: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America

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  • Amy Jenkins,

    Affiliation: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America

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  • Joel A. Bozue,

    Affiliation: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America

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  • Susan L. Welkos,

    Affiliation: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America

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  • Ragini Bhargava,

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Chi-Lee Ho,

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Margarete Mehrabian,

    Affiliation: Department of Human Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Calvin Pan,

    Affiliation: Department of Human Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Aldons J. Lusis,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America, Department of Human Genetics, University of California at Los Angeles, Los Angeles, California, United States of America, Department of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Richard C. Davis,

    Affiliation: Department of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Steven M. LeVine,

    Affiliation: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Kenneth A. Bradley mail

    kbradley@microbio.ucla.edu

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Published: December 29, 2011
  • DOI: 10.1371/journal.ppat.1002469

About the Authors

Jill K. Terra, Bryan France, Ragini Bhargava, Chi-Lee Ho, Aldons J. Lusis, Kenneth A. Bradley
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America
Christopher K. Cote, Amy Jenkins, Joel A. Bozue, Susan L. Welkos
Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America
Margarete Mehrabian, Calvin Pan, Aldons J. Lusis
Department of Human Genetics, University of California at Los Angeles, Los Angeles, California, United States of America
Aldons J. Lusis, Richard C. Davis
Department of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
Steven M. LeVine
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: kbradley@microbio.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKT CKC SLW AJL RCD SML KAB. Performed the experiments: JKT BF CKC AJ JAB SLW RB CLH SML. Analyzed the data: JKT CKC SLW MM CP RCD SML KAB. Contributed reagents/materials/analysis tools: MM CP RCD AJL. Wrote the paper: JKT CKC SLW SML KAB.