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Research Article

Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors

  • Alejandro Buschiazzo mail,

    alebus@pasteur.edu.uy (AB); oscar@iib.unsam.edu.ar (OC)

    Affiliations: Institut Pasteur de Montevideo, Unit of Protein Crystallography, Montevideo, Uruguay, Institut Pasteur, Department of Structural Biology and Chemistry, Paris, France

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  • Romina Muiá,

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina

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  • Nicole Larrieux,

    Affiliation: Institut Pasteur de Montevideo, Unit of Protein Crystallography, Montevideo, Uruguay

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  • Tamara Pitcovsky,

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina

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  • Juan Mucci,

    Affiliations: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Oscar Campetella mail

    alebus@pasteur.edu.uy (AB); oscar@iib.unsam.edu.ar (OC)

    Affiliations: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Published: January 05, 2012
  • DOI: 10.1371/journal.ppat.1002474

About the Authors

Alejandro Buschiazzo, Nicole Larrieux
Institut Pasteur de Montevideo, Unit of Protein Crystallography, Montevideo, Uruguay
Alejandro Buschiazzo
Institut Pasteur, Department of Structural Biology and Chemistry, Paris, France
Romina Muiá, Tamara Pitcovsky, Juan Mucci, Oscar Campetella
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina
Juan Mucci, Oscar Campetella
Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB JM OC. Performed the experiments: AB RM NL TP JM OC. Analyzed the data: AB RM NL TP JM OC. Wrote the paper: AB JM OC.