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Research Article

The RBP-Jκ Binding Sites within the RTA Promoter Regulate KSHV Latent Infection and Cell Proliferation

  • Jie Lu,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Subhash C. Verma,

    Affiliation: Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, Nevada, United States of America

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  • Qiliang Cai,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Abhik Saha,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Richard Kuo Dzeng,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Erle S. Robertson mail

    erle@mail.med.upenn.edu

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: January 12, 2012
  • DOI: 10.1371/journal.ppat.1002479

About the Authors

Jie Lu, Qiliang Cai, Abhik Saha, Richard Kuo Dzeng, Erle S. Robertson
Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Subhash C. Verma
Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, Nevada, United States of America

Corresponding Author

Email: erle@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL SCV ESR. Performed the experiments: JL QC RKD. Analyzed the data: JL SCV. Contributed reagents/materials/analysis tools: AS. Wrote the paper: JL ESR.