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Research Article

The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture

  • Martijn A. Langereis equal contributor,

    equal contributor Contributed equally to this work with: Martijn A. Langereis, Qinghong Zeng

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Qinghong Zeng equal contributor,

    equal contributor Contributed equally to this work with: Martijn A. Langereis, Qinghong Zeng

    Affiliation: Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands

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  • Balthasar Heesters,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Eric G. Huizinga mail,

    e.g.huizinga@uu.nl (EGH); r.j.degroot@uu.nl (RJdG)

    Affiliation: Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands

    X
  • Raoul J. de Groot mail

    e.g.huizinga@uu.nl (EGH); r.j.degroot@uu.nl (RJdG)

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Published: January 26, 2012
  • DOI: 10.1371/journal.ppat.1002492

About the Authors

Martijn A. Langereis, Balthasar Heesters, Raoul J. de Groot
Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Qinghong Zeng, Eric G. Huizinga
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL QZ EGH RJdG. Performed the experiments: MAL QZ BH. Analyzed the data: MAL QZ EGH RJdG. Wrote the paper: MAL QZ EGH RJdG.