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Research Article

Development of Functional and Molecular Correlates of Vaccine-Induced Protection for a Model Intracellular Pathogen, F. tularensis LVS

  • Roberto De Pascalis,

    Affiliation: Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, United States of America

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  • Alicia Y. Chou,

    Affiliation: Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, United States of America

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  • Catharine M. Bosio,

    Affiliation: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana, United States of America

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  • Chiung-Yu Huang,

    Affiliation: Biostatistics Research Branch, Division of Clinical Research, NIAID/NIH, Bethesda, Maryland, United States of America

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  • Dean A. Follmann,

    Affiliation: Biostatistics Research Branch, Division of Clinical Research, NIAID/NIH, Bethesda, Maryland, United States of America

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  • Karen L. Elkins mail

    karen.elkins@fda.hhs.gov

    Affiliation: Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, United States of America

    X
  • Published: January 19, 2012
  • DOI: 10.1371/journal.ppat.1002494

About the Authors

Roberto De Pascalis, Alicia Y. Chou, Karen L. Elkins
Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, United States of America
Catharine M. Bosio
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana, United States of America
Chiung-Yu Huang, Dean A. Follmann
Biostatistics Research Branch, Division of Clinical Research, NIAID/NIH, Bethesda, Maryland, United States of America

Corresponding Author

Email: karen.elkins@fda.hhs.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RDP CMB KLE. Performed the experiments: RDP AYC CMB KLE. Analyzed the data: RDP AYC CMB CYH DAF KLE. Contributed reagents/materials/analysis tools: RDP AYC CMB CYH DAF KLE. Wrote the paper: RDP AYC CMB CYH DAF KLE.