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Research Article

Temporal Expression of Bacterial Proteins Instructs Host CD4 T Cell Expansion and Th17 Development

  • Seung-Joo Lee equal contributor,

    equal contributor Contributed equally to this work with: Seung-Joo Lee, James B. McLachlan

    Affiliation: Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • James B. McLachlan equal contributor,

    equal contributor Contributed equally to this work with: Seung-Joo Lee, James B. McLachlan

    Affiliations: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America, Department of Microbiology & Immunology, Tulane University Health Science Center, New Orleans, Louisiana, United States of America

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  • Jonathan R. Kurtz,

    Affiliation: Department of Microbiology & Immunology, Tulane University Health Science Center, New Orleans, Louisiana, United States of America

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  • Danhua Fan,

    Affiliation: Department of Biostatistics and Informatics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Sebastian E. Winter,

    Affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

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  • Andreas J. Baumler,

    Affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

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  • Marc K. Jenkins,

    Affiliation: Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Stephen J. McSorley mail

    sjmcsorley@ucdavis.edu

    Affiliation: Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Published: January 19, 2012
  • DOI: 10.1371/journal.ppat.1002499

About the Authors

Seung-Joo Lee, Stephen J. McSorley
Center for Comparative Medicine, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
James B. McLachlan, Marc K. Jenkins
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
James B. McLachlan, Jonathan R. Kurtz
Department of Microbiology & Immunology, Tulane University Health Science Center, New Orleans, Louisiana, United States of America
Danhua Fan
Department of Biostatistics and Informatics, University of Minnesota, Minneapolis, Minnesota, United States of America
Sebastian E. Winter, Andreas J. Baumler
Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: sjmcsorley@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJM MKJ. Performed the experiments: SJL JBM JRK SEW. Analyzed the data: SJL JBM JRK DF SEW AJB MKJ SJM. Wrote the paper: SJM SJL JBM.