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Research Article

Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus

  • Daniela Münch,

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology – Pharmaceutical Microbiology Section, University of Bonn, Bonn, Germany

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  • Terry Roemer,

    Affiliation: Department of Infectious Diseases, Merck Research Laboratories, Merck & Co., Kenilworth, New Jersey, United States of America

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  • Sang Ho Lee,

    Affiliation: Department of Infectious Diseases, Merck Research Laboratories, Merck & Co., Kenilworth, New Jersey, United States of America

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  • Marianne Engeser,

    Affiliation: Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany

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  • Hans Georg Sahl,

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology – Pharmaceutical Microbiology Section, University of Bonn, Bonn, Germany

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  • Tanja Schneider mail

    tanja@microbiology-bonn.de

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology – Pharmaceutical Microbiology Section, University of Bonn, Bonn, Germany

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  • Published: January 26, 2012
  • DOI: 10.1371/journal.ppat.1002509

About the Authors

Daniela Münch, Hans Georg Sahl, Tanja Schneider
Institute of Medical Microbiology, Immunology and Parasitology – Pharmaceutical Microbiology Section, University of Bonn, Bonn, Germany
Terry Roemer, Sang Ho Lee
Department of Infectious Diseases, Merck Research Laboratories, Merck & Co., Kenilworth, New Jersey, United States of America
Marianne Engeser
Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany

Corresponding Author

Email: tanja@microbiology-bonn.de

Competing Interests

DM, ME, HGS and TS have declared that no competing interest exist. Terry Roemer is a present employee of Merck as stated in the affiliates and may potentially own stock and/or stock options in the company.

Author Contributions

Conceived and designed the experiments: DM TS TR. Performed the experiments: DM TS TR ME SHL. Analyzed the data: TS TR ME HGS DM SHL. Contributed reagents/materials/analysis tools: HGS TR TS ME. Wrote the paper: TS DM TR HGS.