Advertisement
Research Article

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

  • Ravikiran M. Raju equal contributor,

    equal contributor Contributed equally to this work with: Ravikiran M. Raju, Meera Unnikrishnan

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Meera Unnikrishnan equal contributor,

    equal contributor Contributed equally to this work with: Ravikiran M. Raju, Meera Unnikrishnan

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Daniel H. F. Rubin,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Vidhya Krishnamoorthy,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Olga Kandror,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Tatos N. Akopian,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Alfred L. Goldberg,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Eric J. Rubin mail

    erubin@hsph.harvard.edu

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Published: February 16, 2012
  • DOI: 10.1371/journal.ppat.1002511

About the Authors

Ravikiran M. Raju, Meera Unnikrishnan, Daniel H. F. Rubin, Vidhya Krishnamoorthy, Eric J. Rubin
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Olga Kandror, Tatos N. Akopian, Alfred L. Goldberg
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: erubin@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMR MU ALG EJR. Performed the experiments: RMR MU DHFR VK OK TNA. Analyzed the data: RMR MU EJR. Contributed reagents/materials/analysis tools: EJR ALG TNA OK. Wrote the paper: RMR MU EJR.